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CD002187. pub3. PMID viaagra. Nurnberg HG, Hensley PL, Gelenberg AJ, Fava M, Lauriello J, Paine S January 2003. Treatment of antidepressant-associated sexual dysfunction with baneocin salbe wirkung viagra a randomized controlled trial. JAMA 289 1 : 56‚64. doi:10. 1001jama. 289.

In volunteers with hepatic impairment (Child-Pugh Class A and B), sildenafil clearance was reduced, resulting in higher plasma exposure of sildenafil (47 for C max and 85 for AUC). The pharmacokinetics of sildenafil in patients with severely impaired hepatic function (Child-Pugh Class C) have not been studied. A starting dose of 25 mg should be considered in patients with any degree of hepatic impairment [see DOSAGE AND ADMINISTRATION and CLINICAL PHARMACOLOGY ]. In studies with healthy volunteers of single doses up to 800 mg, adverse reactions were similar to those seen at lower doses but incidence rates and severities were increased. In cases of overdose, standard supportive measures should be adopted as required. Renal dialysis is not expected to accelerate clearance as sildenafil is highly bound to plasma proteins and it is not eliminated in the urine. CONTRAINDICATIONS. Consistent with its known effects on the nitric oxidecGMP pathway [see CLINICAL PHARMACOLOGY ], VIAGRA was shown to potentiate the hypotensive effects of nitrates, and its administration to patients who are using nitric oxide donors such as organic nitrates or organic nitrites in any form either regularly andor intermittently is therefore contraindicated.

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