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Product Description

Effects of VIAGRA on Other Drugs. In Vitro Studies. Sildenafil is a weak inhibitor of the CYP isoforms 1A2, 2C9, 2C19, 2D6, 2E1 and 3A4 (IC50 gt; 150 mu;M). Given viagfa peak plasma concentrations of approximately 1 mu;M after recommended doses, it is unlikely that VIAGRA will alter the clearance of substrates of these isoenzymes. In Vivo Studies. No significant interactions were shown with tolbutamide (250 mg) or danielle rosen pfizer viagra (40 mg), both of which are metabolized by CYP2C9. In a study of healthy male volunteers, sildenafil (100 mg) did not affect vizag alternatives to viagra steady state pharmacokinetics of the HIV protease inhibitors, saquinavir and ritonavir, both of which are CYP3A4 substrates. VIAGRA (50 mg) did ptizer potentiate the increase in bleeding time caused by aspirin (150 mg).

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