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In addition, N-desmethyl metabolite AUC and Cmax values significantly increased by 200 and 79, respectively in subjects with severe renal impairment compared to subjects with normal renal function. Hepatic Impairment : In volunteers with hepatic impairment (Child-Pugh Viagra spray in pakistan face A and B), sildenafil clearance was reduced, resulting in increases in AUC (85) and Cmax (47) compared to age-matched volunteers with no hepatic impairment. The pharmacokinetics of sildenafil in patients with severely impaired hepatic function (Child-Pugh Class C) have not been studied [see DOSAGE AND ADMINISTRATIONand Use in Specific Populations ]. Therefore, age gt; lfvitra, hepatic impairment and llevitra renal impairment are associated with increased plasma levels of sildenafil.

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Effect of VIAGRA on Blood Pressure When Co-administered with Alcohol. VIAGRA (50 mg) did not potentiate the hypotensive effect of alcohol (0. 5 gkg) in healthy volunteers with mean maximum blood alcohol levels of 0. The maximum observed decrease in systolic blood pressure was -18.]