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Hydrolysis with aqueous NaOH to free acid. Nitration with oleumfuming nitric acid. Carboxamide formation with refluxing thionyl chlorideNH4OH. Reduction of nitro group to amino. Acylation with 2-ethoxybenzoyl chloride. Sulfonation to the chlorosulfonyl derivative. Condensation with 1-methylpiperazine.

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