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Detailed information

Sildenafil was not carcinogenic when administered to rats for 24 months at a dose resulting in total systemic drug exposure (AUCs) for unbound sildenafil and its major metabolite of 29-and 42-times, for male and female rats, respectively, the exposures observed in human males given the Maximum Recommended Human Dose (MRHD) of 100 mg. Sildenafil was not carcinogenic when administered to mice for 18-21 months at dosages up to the Maximum Tolerated Dose (MTD) of 10 mgkgday, approximately 0. 6 times the MRHD on a mgmsup2; basis. Mutagenesis.

Keith K.February 20, 2016. Reviews from our users, collected this week. Click on the red tab on the left for more reviews.

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