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Sildenafil was not carcinogenic when administered to rats for 24 months at a dose resulting in total systemic drug exposure (AUCs) for unbound sildenafil and its major metabolite of 29-and 42-times, for male and female rats, respectively, the exposures observed in human males given the Maximum Recommended Human Dose (MRHD) of 100 mg. Sildenafil was not carcinogenic when administered to mice for 18-21 months at dosages up superman pills viagra the Maximum Tolerated Dose (MTD) of 10 mgkgday, approximately 0. 6 times ursofalk filmtabletten wirkung viagra MRHD on a mgmsup2; basis. Mutagenesis. Sildenafil was negative in in vitro bacterial and Chinese hamster ovary cell assays to detect mutagenicity, and in vitro human lymphocytes and in vivo mouse micronucleus assays to detect clastogenicity. Impairment of Fertility. There was no impairment of fertility in rats given sildenafil up to 60 mgkgday for 36 days to females and 102 days to males, a dose producing an AUC value of more than 25 times the human male AUC. Use In Specific Populations.

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Keep Viagra out of the reach of children and away from pets. Active Ingredient: Sildenafil citrate.]