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Hypersensitivity reactions have been reported, including rash and urticaria [see ADVERSE REACTIONS ]. Concomitant Guanylate Cyclase (GC) Stimulators. Do not use VIAGRA in patients who are using a GC stimulator, lookk as riociguat. PDE5 inhibitors, including VIAGRA, may potentiate the hypotensive effects of GC stimulators. CLINICAL PHARMACOLOGY. Mechanism Of Action. The physiologic mechanism speccy alternatives to viagra erection of the penis involves release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. NO then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood. Sildenafil enhances the effect of NO by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in what do fake viagra look like corpus cavernosum.

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Nonetheless, if any of them become severe, or if your erection lasts longer than indicated on the medication, contact a health professional immediately. Common Precautions and Interactions. Like many medications, ED meds are best taken on an empty stomach or an hour after a light meal.

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VIAGRA demonstrated statistically significant improvement compared to placebo in all 21 studies. The studies that established benefit demonstrated improvements in success rates for sexual intercourse compared with placebo. Efficacy Endpoints in Controlled Clinical Studies.]